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Engineering    2017, Vol. 3 Issue (1) : 83-89     https://doi.org/10.1016/J.ENG.2017.01.013
Research |
病理状态下肠道微生态的调节
王玉兰1,2(),王保红2,吴俊芳1,江向洋2,唐惠儒3,Nielsen Ole H.4
1. Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, China
2. National Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
3. State Key Laboratory of Genetic Engineering, Zhongshan Hospital and School of Life Sciences, Fudan University, Collaborative Innovation Center of Genetics and Development, Shanghai International Center for Molecular Phenomics, Shanghai 200433, China
4. Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Copenhagen 1017, Denmark
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摘要 

人类微生态是寄居在人体中的微生物聚集体,且主要存在于胃肠道(GIT) 中。肠道微生态随着人体发育而演化,并在人类健康和疾病中起着重要作用。近年来,由于微生态会影响宿主代谢、生理学和免疫系统发育,而且微生态紊乱可能导致许多疾病,其越来越受到人们的关注。肠道微生态可能与恶性肿瘤有一定联系,如胃癌和结直肠癌;也可能与其他一些疾病有关,如非酒精性脂肪肝(NAFLD)、被称为工业化世界“生活方式疾病”的肥胖和糖尿病、冠心病以及中枢神经系统紊乱。虽然分子技术革命为我们更准确地研究肠道微生态提供了必要的工具,但是我们需要更精确地阐明其与某些人类疾病病理变化的关系,明确微生态在不同疾病中的作用是新的治疗策略发展的基础。本文概述了肠道微生态对人类健康的重要影响以及调整肠道菌群结构的潜在用途,如菌群移植用于治疗耐药艰难梭菌(C. difficile) 的感染。通过微生态干预调整肠道区域以改善人类健康的概念虽刚刚兴起,但其治疗意义显著。因此,抑制有害菌、促进有益菌可能会保护人类健康,并且这些努力将为探索发展更加合理的治疗方案打下基础。

关键词 肠道菌群疾病菌群调节    
Abstract

The human microbiota is an aggregate of microorganisms residing in the human body, mostly in the gastrointestinal tract (GIT). Our gut microbiota evolves with us and plays a pivotal role in human health and disease. In recent years, the microbiota has gained increasing attention due to its impact on host metabolism, physiology, and immune system development, but also because the perturbation of the microbiota may result in a number of diseases. The gut microbiota may be linked to malignancies such as gastric cancer and colorectal cancer. It may also be linked to disorders such as nonalcoholic fatty liver disease (NAFLD); obesity and diabetes, which are characterized as “lifestyle diseases” of the industrialized world; coronary heart disease; and neurological disorders. Although the revolution in molecular technologies has provided us with the necessary tools to study the gut microbiota more accurately, we need to elucidate the relationships between the gut microbiota and several human pathologies more precisely, as understanding the impact that the microbiota plays in various diseases is fundamental for the development of novel therapeutic strategies. Therefore, the aim of this review is to provide the reader with an updated overview of the importance of the gut microbiota for human health and the potential to manipulate gut microbial composition for purposes such as the treatment of antibiotic-resistant Clostridium difficile (C. difficile) infections. The concept of altering the gut community by microbial intervention in an effort to improve health is currently in its infancy. However, the therapeutic implications appear to be very great. Thus, the removal of harmful organisms and the enrichment of beneficial microbes may protect our health, and such efforts will pave the way for the development of more rational treatment options in the future.

Keywords Gut microbes      Diseases      Microbial modulation     
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通讯作者: 王玉兰     E-mail: yulan.wang@wipm.ac.cn
最新录用日期:    在线预览日期:    发布日期: 2017-03-02
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引用本文:   
Yulan Wang,Baohong Wang,Junfang Wu, et al. Modulation of Gut Microbiota in Pathological States[J]. Engineering, 2017, 3(1): 83-89.
网址:  
http://engineering.org.cn/EN/10.1016/J.ENG.2017.01.013     OR     http://engineering.org.cn/EN/Y2017/V3/I1/83
Fig.1  Summary of the role of gut microbes and their modulation in a pathological state.
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