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Engineering    2016, Vol. 2 Issue (1) : 141 -148
Research |
Application of Biomaterials in Cardiac Repair and Regeneration
Zhi Cui1,3,Baofeng Yang2,Ren-Ke Li1,3,()
1. Institute of Medical Science & Department of Surgery, Division of Cardiovascular Surgery, University of Toronto, Toronto, ON M5G 2M9, Canada
2. Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin 150001, China
3. Division of Cardiovascular Surgery, Toronto General Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada

Cardiovascular disease is a leading cause of death throughout the world. The demand for new therapeutic interventions is increasing. Although pharmacological and surgical interventions dramatically improve the quality of life of cardiovascular disease patients, cheaper and less invasive approaches are always preferable. Biomaterials, both natural and synthetic, exhibit great potential in cardiac repair and regeneration, either as a carrier for drug delivery or as an extracellular matrix substitute scaffold. In this review, we discuss the current treatment options for several cardiovascular diseases, as well as types of biomaterials that have been investigated as potential therapeutic interventions for said diseases. We especially highlight investigations into the possible use of conductive polymers for correcting ischemic heart disease-induced conduction abnormalities, and the generation of biological pacemakers to improve the conduction pathway in heart block.

Keywords Myocardial infarction      Heart regeneration      Biomaterial      Tissue engineering      Stem cell     
Corresponding Authors: Ren-Ke Li   
Just Accepted Date: 30 March 2016   Issue Date: 05 April 2016
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Zhi Cui
Baofeng Yang
Ren-Ke Li
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Zhi Cui,Baofeng Yang,Ren-Ke Li. Application of Biomaterials in Cardiac Repair and Regeneration[J]. Engineering, 2016, 2(1): 141 -148 .
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