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Engineering    2017, Vol. 3 Issue (1) : 16 -27
Research |
Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies
Jorge L. Escobar Ivirico1,2,3,Maumita Bhattacharjee1,2,3,Emmanuel Kuyinu1,2,3,Lakshmi S. Nair1,2,3,4,5,Cato T. Laurencin1,2,3,4,5,6,7,8()
1. Institute for Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USA
2. Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA
3. Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
4. Department of Biomedical Engineering, School of Engineering, University of Connecticut, Storrs, CT 06269, USA
5. Department of Materials Science and Engineering, School of Engineering, University of Connecticut, Storrs, CT 06269, USA
6. Institute of Materials Science, University of Connecticut, Storrs, CT 06269, USA
7. Department of Craniofacial Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
8. Department of Chemical and Biomolecular Engineering, School of Engineering, University of Connecticut, Storrs, CT 06269, USA

Knee osteoarthritis (OA) is the most common form of arthritis worldwide. The incidence of this disease is rising and its treatment poses an economic burden. Two early targets of knee OA treatment include the predominant symptom of pain, and cartilage damage in the knee joint. Current treatments have been beneficial in treating the disease but none is as effective as total knee arthroplasty (TKA). However, while TKA is an end-stage solution of the disease, it is an invasive and expensive procedure. Therefore, innovative regenerative engineering strategies should be established as these could defer or annul the need for a TKA. Several biomaterial and cell-based therapies are currently in development and have shown early promise in both preclinical and clinical studies. The use of advanced biomaterials and stem cells independently or in conjunction to treat knee OA could potentially reduce pain and regenerate focal articular cartilage damage. In this review, we discuss the pathogenesis of pain and cartilage damage in knee OA and explore novel treatment options currently being studied, along with some of their limitations.

Keywords Knee osteoarthritis      Osteoarthritic pain      Mesenchymal stem cells      Biomaterials      Regenerative engineering     
Corresponding Authors: Cato T. Laurencin   
Just Accepted Date: 14 February 2017   Online First Date: 16 February 2017    Issue Date: 02 March 2017
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Jorge L. Escobar Ivirico
Maumita Bhattacharjee
Emmanuel Kuyinu
Lakshmi S. Nair
Cato T. Laurencin
Cite this article:   
Jorge L. Escobar Ivirico,Maumita Bhattacharjee,Emmanuel Kuyinu, et al. Regenerative Engineering for Knee Osteoarthritis Treatment: Biomaterials and Cell-Based Technologies[J]. Engineering, 2017, 3(1): 16 -27 .
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