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Engineering    2017, Vol. 3 Issue (1) : 71 -82     https://doi.org/10.1016/J.ENG.2017.01.008
Research |
The Human Microbiota in Health and Disease
Baohong Wang,Mingfei Yao,Longxian Lv,Zongxin Ling,Lanjuan Li()
National Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
Abstract
Abstract  

Trillions of microbes have evolved with and continue to live on and within human beings. A variety of environmental factors can affect intestinal microbial imbalance, which has a close relationship with human health and disease. Here, we focus on the interactions between the human microbiota and the host in order to provide an overview of the microbial role in basic biological processes and in the development and progression of major human diseases such as infectious diseases, liver diseases, gastrointestinal cancers, metabolic diseases, respiratory diseases, mental or psychological diseases, and autoimmune diseases. We also review important advances in techniques associated with microbial research, such as DNA sequencing, metabonomics, and proteomics combined with computation-based bioinformatics. Current research on the human microbiota has become much more sophisticated and more comprehensive. Therefore, we propose that research should focus on the host-microbe interaction and on cause-effect mechanisms, which could pave the way to an understanding of the role of gut microbiota in health and disease. and provide new therapeutic targets and treatment approaches in clinical practice.

Keywords Microbiome      Health      Infectious disease      Liver diseases      Gastrointestinal malignancy      Metabolic disorder      Microbiota technology      Probiotics     
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Corresponding Authors: Lanjuan Li   
Just Accepted Date: 20 February 2017   Online First Date: 01 March 2017    Issue Date: 02 March 2017
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Baohong Wang
Mingfei Yao
Longxian Lv
Zongxin Ling
Lanjuan Li
Cite this article:   
Baohong Wang,Mingfei Yao,Longxian Lv, et al. The Human Microbiota in Health and Disease[J]. Engineering, 2017, 3(1): 71 -82 .
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http://engineering.org.cn/EN/10.1016/J.ENG.2017.01.008     OR     http://engineering.org.cn/EN/Y2017/V3/I1/71
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