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Engineering    2017, Vol. 3 Issue (1) : 28 -35
Research |
Recent Progress in Cartilage Tissue Engineering—Our Experience and Future Directions
Yu Liu1,2,3,Guangdong Zhou1,2,3,Yilin Cao1,2,4()
1. Shanghai Key Laboratory of Tissue Engineering, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
2. National Tissue Engineering Research Center of China, Shanghai 200241, China
3. Research Institute of Plastic Surgery, Plastic Surgery Hospital, Weifang Medical University, Weifang, Shandong 261041, China
4. Plastic Surgery Hospital, Chinese Academy of Medical Science, Beijing 100144, China

Given the limited spontaneous repair that follows cartilage injury, demand is growing for tissue engineering approaches for cartilage regeneration. There are two major applications for tissue-engineered cartilage. One is in orthopedic surgery, in which the engineered cartilage is usually used to repair cartilage defects or loss in an articular joint or meniscus in order to restore the joint function. The other is for head and neck reconstruction, in which the engineered cartilage is usually applied to repair cartilage defects or loss in an auricle, trachea, nose, larynx, or eyelid. The challenges faced by the engineered cartilage for one application are quite different from those faced by the engineered cartilage for the other application. As a result, the emphases of the engineering strategies to generate cartilage are usually quite different for each application. The statuses of preclinical animal investigations and of the clinical translation of engineered cartilage are also at different levels for each application. The aim of this review is to provide an opinion piece on the challenges, current developments, and future directions for cartilage engineering for both applications.

Keywords Cartilage tissue engineering      Preclinical immunocompetent animal      investigation      Clinical translation      Orthopedic surgery      Head and neck reconstruction     
Corresponding Authors: Yilin Cao   
Just Accepted Date: 21 February 2017   Online First Date: 27 February 2017    Issue Date: 02 March 2017
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Yu Liu,Guangdong Zhou,Yilin Cao. Recent Progress in Cartilage Tissue Engineering—Our Experience and Future Directions[J]. Engineering, 2017, 3(1): 28 -35 .
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