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Engineering    2017, Vol. 3 Issue (3) : 308 -317
Research |
Advances in Cadaverine Bacterial Production and Its Applications
Weichao Ma1,2,3,Kequan Chen1,2(),Yan Li1,2,Ning Hao1,2,Xin Wang1,2,Pingkai Ouyang1,2
1. State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 211816, China
2. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China
3. College of Bioengineering and Biotechnology, Tianshui Normal University, Tianshui 741001, China

Cadaverine, a natural polyamine with multiple bioactivities that is widely distributed in prokaryotes and eukaryotes, is becoming an important industrial chemical. Cadaverine exhibits broad prospects for various applications, especially as an important monomer for bio-based polyamides. Cadaverine-based polyamide PA 5X has broad application prospects owing to its environmentally friendly characteristics and exceptional performance in water absorption and dimensional stability. In this review, we summarize recent findings on the biosynthesis, metabolism, and physiological function of cadaverine in bacteria, with a focus on the regulatory mechanism of cadaverine synthesis in Escherichia coli (E. coli). We also describe recent developments in bacterial production of cadaverine by direct fermentation and whole-cell bioconversion, and recent approaches for the separation and purification of cadaverine. In addition, we present an overview of the application of cadaverine in the synthesis of completely bio-based polyamides. Finally, we provide an outlook and suggest future developments to advance the production of cadaverine from renewable resources.

Keywords Cadaverine      Metabolism      Bacterial production      Bio-polyamide      PA 5X     
Corresponding Authors: Kequan Chen   
Just Accepted Date: 23 May 2017   Issue Date: 30 June 2017
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Weichao Ma
Kequan Chen
Yan Li
Ning Hao
Xin Wang
Pingkai Ouyang
Cite this article:   
Weichao Ma,Kequan Chen,Yan Li, et al. Advances in Cadaverine Bacterial Production and Its Applications[J]. Engineering, 2017, 3(3): 308 -317 .
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