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Engineering    2017, Vol. 3 Issue (3) : 354 -364     https://doi.org/10.1016/J.ENG.2017.03.023
Research |
Progress of Pharmaceutical Continuous Crystallization
Dejiang Zhang1,2,Shijie Xu1,2,Shichao Du1,2,Jingkang Wang1,2,Junbo Gong1,2()
1. School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China
2. Collaborative Innovation Center of Chemical Science and Chemical Engineering, Tianjin University, Tianjin 300072, China
Abstract
Abstract  

Crystallization is an important unit operation in the pharmaceutical industry. At present, most pharmaceutical crystallization processes are performed in batches. However, due to product variability from batch to batch and to the low productivity of batch crystallization, continuous crystallization is gaining increasing attention. In the past few years, progress has been made to allow the products of continuous crystallization to meet different requirements. This review summarizes the progress in pharmaceutical continuous crystallization from a product engineering perspective. The advantages and disadvantages of different types of continuous crystallization are compared, with the main difference between the two main types of crystallizers being their difference in residence time distribution. Approaches that use continuous crystallization to meet different quality requirements are summarized. Continuous crystallization has advantages in terms of size and morphology control. However, it also has the problem of a process yield that may be lower than that of a batch process, especially in the production of chirality crystals. Finally, different control strategies are compared.

Keywords Continuous crystallization      Pharmaceutical      MSMPR      Tubular crystallizer      Control strategy     
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Corresponding Authors: Junbo Gong   
Just Accepted Date: 19 June 2017   Issue Date: 30 June 2017
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Dejiang Zhang
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Junbo Gong
Cite this article:   
Dejiang Zhang,Shijie Xu,Shichao Du, et al. Progress of Pharmaceutical Continuous Crystallization[J]. Engineering, 2017, 3(3): 354 -364 .
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http://engineering.org.cn/EN/10.1016/J.ENG.2017.03.023     OR     http://engineering.org.cn/EN/Y2017/V3/I3/354
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