Exploring Shaking for Cancer Treatment

2024, Volume 38, Issue 7

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Engineering doi: 10.1016/j.eng.2024.04.001

Exploring Shaking for Cancer Treatment

^aDepartment of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
^bIndiana University Simon Comprehensive Cancer Center & Indiana Center for Musculoskeletal Health, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
^cState Key Laboratory of Frigid Zone Cardiovascular Diseases, Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin 150081, China

Received: 2024-01-31 Revised: 2024-04-04 Accepted: 2024-04-06 Available online: 2024-04-16

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Abstract

Presently, cancer treatment encompasses diverse approaches like surgery, chemotherapy, radiotherapy, targeted therapy, immunotherapy, and adjunctive methods such as massage and physical exercises targeting specific tissues or the whole body. A key inquiry emerges: could introducing vibration and shaking of patientderived cells introduce a novel dimension to conventional cancer treatments? To delve into this prospect, conducting thorough vibration and molecular signaling analyses becomes imperative. Understanding whether vibration is optimally effective at resonance frequencies and assessing how the viscous cell culture medium enhances responses in these cells are crucial inquiries. Addressing these queries holds promise in advancing vibration-driven iTS cell-mediated cancer treatments.

Keywords

Cell engineering ; Vibration & Shaking ; Induced pluripotent stem (iPS) cells ; Induced tumor-suppressing (iTS) cells ; Cancer treatment ; Chimeric antigen receptor (CAR)-T cell immunotherapy

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