For flow-related design optimization problems, e.g., aircraft and automobile aerodynamic design, computational fluid dynamics (CFD) simulations are commonly used to predict flow fields and analyze performance. While important, CFD simulations are a resource-demanding and time-consuming iterative process. The expensive simulation overhead limits the opportunities for large design space exploration and prevents interactive design. In this paper, we propose FlowDNN, a novel (DNN) to efficiently learn flow representations from CFD results. FlowDNN saves computational time by directly predicting the expected flow fields based on given flow conditions and geometry shapes. FlowDNN is the first DNN that incorporates the underlying physical conservation laws of fluid dynamics with a carefully designed for steady . This approach not only improves the prediction accuracy, but also preserves the physical consistency of the predicted flow fields, which is essential for CFD. Various metrics are derived to evaluate FlowDNN with respect to the whole flow fields or regions of interest (RoIs) (e.g., boundary layers where flow quantities change rapidly). Experiments show that FlowDNN significantly outperforms alternative methods with faster inference and more accurate results. It speeds up a graphics processing unit (GPU) accelerated CFD solver by more than , while keeping the prediction error under 5%.