2014, Volume 16, Issue 5
Strategic Study of CAE >> 2014, Volume 16, Issue 5
The effect of HCG-day serum progesterone and estradiol concentrations on pregnancy outcomes in IVF/ICSI-ET cycles
Reproductive Medicine Center in Renmin Hospital of Wuhan University，Wuhan 430060，China
Next Previous
Abstract
To evaluate the effect of serum progesterone and estradiol concentrations on day of injecting human chorionic gonadotropinon(HCG) on the pregnancy outcomes in the invitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) patients. From Sep. 2011 to Sep.2012，1 270 fresh IVF cycles who comply with relevant conditions were analyzed retrospectively in Reproductive Medicine Center in Renmin Hospital of Wuhan University. And according to the serum progesterone value，the patients are divided into two groups，One group is the value of serum progestrone which is less than 2.0 pg/mL on the day of injecting HCG，the other is the value of serum progestrone which is equal or greater than 2.0 pg/mL on the day of injecting HCG.Then in terms of the ratio about progesterone and estradiol (P/E2)，the patients are divided into two groups with 0.6 as P/E2 cut-off point. Compared women’s age，duration of infertility，basic follicle stimulating hormone (FSH) values，the total doses of gonadotropin，the duration of stimulation，number of oocytes retrieved，number of MII oocytes，number of fertilization，number of cleavage，number of high qualified embryo，number of embryos transferred per cycle，estradiol level on the HCG day，clinical pregnancy rate (%)，embryo implantation rate (%). The higher concentration of progesterone group had more total doses of gonadotropin，duration of stimulation，number of oocytes retrieved，number of MII oocytes，number of cleavage，E2 value，but the clinical pregnancy rate, embryo implantation rate were statistically decrease.There was an increase in the age of female patien, basic FSH values and total doses of gonadotropin, duration of stimulation,number of oocytes retrieved, number of fertilization,number of high qualified embryo，P values in higher P/E2 ratio group. However, there was no obvious difference was found between the pregnancy outcome. Conclusion on day of injecting HCG，serum progesterone levels can reduce clinical pregnancy rates and embryo implantation rate.
Keywords
the value of serum progestrone ; on day of injecting HCG ; fresh IVF/ICSI cycles ; clinical pregnancy rate
Figures
图1
图2
References
[ 1 ] Aflatoonian A，Oskouian H，Ahmadi S，et al. Can fresh embryo transfers be replaced by cryopreserved-thawed embryo transfers in assisted reproductive cycles? A randomized controlled trial [J]. Journal of Assisted Reproduction and Genetics，2010，27(7)： 357-363. link1
[ 2 ] Cetinkaya E S，Berker B，Aytac R，et al. The value of the progesterone-to-estradiol ratio on the day of HCG administration in predicting ongoing pregnancy and live birth rates in normoresponders undergoing GnRH antagonist cycles [J]. European Journal of Obstetrics & Gynecology and Reproductive Biology， 2013，170(2)：452-457. link1
[ 3 ] Papanikolaou E G，Pados G，Grimbizis G，et al. GnRH-agonist versus GnRH- antagonist IVF cycles：Is the reproductive outcome affected by the incidence of progesterone elevation on the day of HCG triggering? A randomized prospective study [J]. Human Reproduction，2012，27(6)：1822-1828. link1
[ 4 ] Fleming R，Jenkins J，Julian Jenkins，et al. The source and implications of progesterone rise during the follicular phase of assisted reproduction cycles [J]. Reproductive Biomedicine Online， 2010，21(4)：446-449. link1
[ 5 ] Younis J S，Simon A，Laufer N. Endometrial preparation：Lessons from oocyte donation [J]. Fertility and Sterility，1996，66 (6)：873-884. link1
[ 6 ] Kiliçdag E B，Haydardedeoglu B，Cok T，et al. Premature progesterone elevation impairs implantation and live birth rates in GnRH-agonist IVF/ICSI cycles [J]. Archives of Gynecology and Obstetrics，2010，281(4)：747-752. link1
[ 7 ] Martínez F，Coroleu B，Clua E，et al. Serum progesterone concentrations on the day of HCG administration cannot predict pregnancy in assisted reproduction cycles [J]. Reproductive Biomedicine Online，2004，8(2)：183-190. link1
[ 8 ] Doldi N，Marsiglio E，Destefani A，et al. Elevated serum progesterone on the day of HCG administration in IVF is associated with a higher pregnancy rate in polycystic ovary syndrome [J]. Human Reproduction，1999，14(3)：601-605. link1
[ 9 ] Lee F K，Lai T H，Lin T K，et al. Relationship of progesterone/ estradiol ratio on day of hCG administration and pregnancy outcomes in high responders undergoing in vitro fertilization [J]. Fertility and Sterility，2009，92(4)：1284-1289. link1
[10] OzturkS，Demir R. Particular functions of estrogen and progesterone in establishment of uteriner eceptivity and embryo implantation [J]. Histol Histopathol，2010，25：1215-1228. link1
[11] Melo M A B，Meseguer M，Garrido N，et al. The significance of premature luteinization in an oocyte-donation programme [J]. Human Reproduction，2006，21(6)：1503-1507. link1
[12] Li R，Qiao J，Wang L，et al. Serum progesterone concentration on day of HCG administration and IVF outcome [J]. Reproductive Biomedicine Online，2008，16(5)：627-631. link1
[13] Nikas G，Makrigiannakis A. Endometrial pinopodes and uterine receptivity [J]. Annals of the New York Academy of Sciences， 2003，997(1)：120-123. link1
[14] Labarta E，Martínez-Conejero J A，Alamá P，et al. Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase：A functional genomics analysis [J]. Human Reproduction，2011，26(7)：1813- 1825. link1
[15] Macklon N S，van der Gaast M H，Hamilton A，et al. The impact of ovarian stimulation with recombinant FSH in combination with GnRH antagonist on the endometrial transcriptome in the window of implantation [J]. Reproductive Sciences，2008， 15(4)：357-365. link1
京公网安备 11010502051620号
