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Frontiers of Medicine >> 2021, Volume 15, Issue 4 doi: 10.1007/s11684-020-0809-2
Bavachin enhances NLRP3 inflammasome activation induced by ATP or nigericin and causes idiosyncratic hepatotoxicity
. China Military Institute of Chinese Materia, the Fifth Medical Centre, Chinese PLA General Hospital, Beijing 100039, China.. Department of Pharmacy, Nantong Hospital of Traditional Chinese Medicine, Nantong 226300, China.. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China.. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.. Research Center for Clinical and Translational Medicine, the Fifth Medical Centre, Chinese PLA General Hospital, Beijing 100039, China.. School of Traditional Chinese Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.. Integrative Medical Centre, the Fifth Medical Centre, Chinese PLA General Hospital, Beijing 100039, China
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Keywords
Psoraleae Fructus ; bavachin ; idiosyncratic drug-induced liver injury ; caspase-1 ; IL-1β ; NLRP3 inflammasome
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