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Engineering doi: 10.1016/j.eng.2024.05.005
Therapeutic Targeting of PKM2 Ameliorates NASH Fibrosis Progression in A Macrophage-Specific and Liver-Specific Manner
a State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou 510632, China
b Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China
c Department of Microbiology and Immunology, School of Medicine, Jinan University, Guangzhou 510632, China
d Department of Liver Transplantation, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510630, China
e Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Jinan University, Guangzhou 510630, China
Abstract
Keywords
Pyruvate kinase M2 ; Macrophages ; nonparenchymal cells ; heteroduplex oligonucleotide ; Nonalcoholic steatohepatitis ; Liver fibrosis
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