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Unnormalized and normalized forms of gefura measures in directed and undirected networks
Raf GUNS,Ronald ROUSSEAU
Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 4, Pages 311-320 doi: 10.1631/FITEE.1400425
Keywords: Networks subdivided in groups Partitions Gefura measures Q-measures Brokerage role Directed and
Deeply missing my career idol and role model ― Professor Perry L. McCarty
Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 9, doi: 10.1007/s11783-023-1717-x
Appreciating the role of big data in the modernization of environmental governance
Frontiers of Engineering Management 2022, Volume 9, Issue 1, Pages 163-169 doi: 10.1007/s42524-021-0185-x
The critical role of autophagy in plant responses to abiotic stresses
Yu WANG,Jie ZHOU,Jingquan YU
Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 1, Pages 28-36 doi: 10.15302/J-FASE-2017130
Keywords: abiotic stresses autophagy extreme temperature nutrient starvation osmotic stress oxidative stress
Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 7, doi: 10.1007/s11783-023-1686-0
● Lipid can promote PA production on a target from food waste.
Keywords: Acidogenic fermentation Microbial community Volatile fatty acid Propionate Food waste Lipid
The role of EcoCampus in addressing sustainability in UK universities
Peter REDFERN, Hua ZHONG
Frontiers of Engineering Management 2017, Volume 4, Issue 2, Pages 193-200 doi: 10.15302/J-FEM-2017038
Keywords: EcoCampus environmental management sustainable development carbon management
A distinct “repair” role of regulatory T cells in fracture healing
Frontiers of Medicine 2024, Volume 18, Issue 3, Pages 516-537 doi: 10.1007/s11684-023-1024-8
Keywords: regulatory T cells fracture healing amphiregulin non-union osteogenesis
Friederike WALL
Frontiers of Information Technology & Electronic Engineering 2016, Volume 17, Issue 4, Pages 283-295 doi: 10.1631/FITEE.1500306
Keywords: Agent-based simulation Complexity Coordination Distributed search NK landscapes
The role of manganese oxides in the activation of peroxymonosulfate (PMS)
Jianzhi Huang, Huichun Zhang
Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 5, doi: 10.1007/s11783-019-1158-8
Keywords: Peroxymonosulfate Manganese oxides Catalyst Oxidant
Mechanism of insulin resistance in obesity: a role of ATP
Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 372-382 doi: 10.1007/s11684-021-0862-5
Keywords: type 2 diabetes energy expenditure mitochondria hyperinsulinemia hyperglucagonemia AMPK
The role of microRNAs in adipocyte differentiation
Rong Zhang, Di Wang, Zhuying Xia, Chao Chen, Peng Cheng, Hui Xie, Xianghang Luo
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 223-230 doi: 10.1007/s11684-013-0252-8
Adipocytes differentiate from mesenchymal stem cells (MSCs) in a process known as adipogenesis. The programme of adipogenesis is regulated by the sequential activation of transcription factors and several signaling pathways. There is growing evidence indicating that a class of small non-coding single-stranded RNAs known as “microRNAs (miRNAs)” also are involved in this process. In this review, we summarize the biology and functional mechanisms of miRNAs in adipocyte differentiation. In addition, we further discuss the miRNAs profiling, the miRNAs function and miRNAs target prediction in the adipogenesis.
Keywords: microRNA adipocyte differentiation adipogenesis
The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia
Jessica Fredericks, Ruibao Ren
Frontiers of Medicine 2013, Volume 7, Issue 4, Pages 452-461 doi: 10.1007/s11684-013-0304-0
BCR/ABL is the causative agent of chronic myelogenous leukemia (CML). Through structure/function analysis, several protein motifs have been determined to be important for the development of leukemogenesis. Tyrosine177 of BCR is a Grb2 binding site required for BCR/ABL-induced CML in mice. In the current study, we use a mouse bone marrow transduction/transplantation system to demonstrate that addition of oncogenic NRAS (NRASG12D) to a vector containing a BCR/ABLY177F mutant “rescues” the CML phenotype rapidly and efficiently. To further narrow down the pathways downstream of RAS that are responsible for this rescue effect, we utilize well-characterized RAS effector loop mutants and determine that the RAL pathway is important for rapid induction of CML. Inhibition of this pathway by a dominant negative RAL is capable of delaying disease progression. Results from the present study support the notion of RAL inhibition as a potential therapy for BCR/ABL-induced CML.
Keywords: BCR/ABL chronic myelogenous leukemia (CML) RAS RAL
Maryam ZANDIYEHVAKILI, Isa HOJAT, Mehdi MAHMUDI
Frontiers of Structural and Civil Engineering 2019, Volume 13, Issue 3, Pages 716-724 doi: 10.1007/s11709-018-0508-0
Keywords: architectural-structural interaction geometrical features structure architectural form Iranian ancient architecture
The role of ions in plasma catalytic carbon nanotube growth: A review
Erik C. Neyts
Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 2, Pages 154-162 doi: 10.1007/s11705-015-1515-5
Keywords: plasma-enhanced chemical vapor deposition (PECVD) carbon nanotube (CNT) ion bombardment defect healing
Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells
Sumedha Roy, Yuan Zhuang
Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 374-386 doi: 10.1007/s11684-018-0652-x
A family of transcription factors known as Id proteins, or inhibitor of DNA binding and differentiation, is capable of regulating cell proliferation, survival and differentiation, and is often upregulated in multiple types of tumors. Due to their ability to promote self-renewal, Id proteins have been considered as oncogenes, and potential therapeutic targets in cancer models. On the contrary, certain Id proteins are reported to act as tumor suppressors in the development of Burkitt’s lymphoma in humans, and hepatosplenic and innate-like T cell lymphomas in mice. The contexts and mechanisms by which Id proteins can serve in such contradictory roles to determine tumor outcomes are still not well understood. In this review, we explore the roles of Id proteins in lymphocyte development and tumorigenesis, particularly with respect to inhibition of their canonical DNA binding partners known as E proteins. Transcriptional regulation by E proteins, and their antagonism by Id proteins, act as gatekeepers to ensure appropriate lymphocyte development at key checkpoints. We re-examine the derailment of these regulatory mechanisms in lymphocytes that facilitate tumor development. These mechanistic insights can allow better appreciation of the context-dependent roles of Id proteins in cancers and improve considerations for therapy.
Keywords: Id proteins lymphoma leukemia T cells B cells tumor suppressor oncogene
Title Author Date Type Operation
Unnormalized and normalized forms of gefura measures in directed and undirected networks
Raf GUNS,Ronald ROUSSEAU
Journal Article
The critical role of autophagy in plant responses to abiotic stresses
Yu WANG,Jie ZHOU,Jingquan YU
Journal Article
The role of lipids in fermentative propionate production from the co-fermentation of lipid and food waste
Journal Article
The role of EcoCampus in addressing sustainability in UK universities
Peter REDFERN, Hua ZHONG
Journal Article
Organizational dynamics in adaptive distributed search processes: effects on performance and the role
Friederike WALL
Journal Article
The role of manganese oxides in the activation of peroxymonosulfate (PMS)
Jianzhi Huang, Huichun Zhang
Journal Article
The role of microRNAs in adipocyte differentiation
Rong Zhang, Di Wang, Zhuying Xia, Chao Chen, Peng Cheng, Hui Xie, Xianghang Luo
Journal Article
The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia
Jessica Fredericks, Ruibao Ren
Journal Article
The role of geometrical features in the architectural-structural interaction: Some case studies of the
Maryam ZANDIYEHVAKILI, Isa HOJAT, Mehdi MAHMUDI
Journal Article