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mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 221-231 doi: 10.1007/s11684-020-0812-7

Abstract: Beyond early findings on induced activation of PI3K/Akt, MEK/ERK, and Mnk/eIF4E survival signaling pathwaysthat compromise the efficacy of rapalog-based cancer therapy, recent findings on the essential role of GSK3

Keywords： mTOR     cancer therapy     resistance     GSK3     protein degradation     E3 ubiquitin ligase     PD-L1    

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Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 444-456 doi: 10.1007/s11684-015-0421-z

Abstract: upregulation of β-catenin and P-Akt expression and the TAC- or ANG II-induced downregulation of GSK-3β.

Keywords： aspirin     Akt     cardiac hypertrophy     GSK-3β     Wnt/β-catenin    

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Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4,   Pages 343-348 doi: 10.1007/s11705-007-0062-0

Abstract: An oxetane-derived monomer, 3-acryloyloxymethyl-3′-methyloxetane (AMO) was prepared from the reactionof 3-hydromethyl-3-methyloxetane with acryloyl chloride.The cationic ring-opening copolymerization of AMO with another oxetane-derived monomer, 3-(2-(2-(2-methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane (MEMO) was conducted in CHCl solution using BF3 ·OEt/1, 4-butanediol

Keywords： 4-butanediol     2-methoxyethylenoxy     consistent     oxetane-derived     copolymer    

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Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 95-99 doi: 10.1007/s11684-008-0017-y

Abstract: The Sj14-3-3 gene was amplified and subcloned into the expression vector pPICZ?The protein of rSj14-3-3 was prepared and purified and BALB/c mice were immunized which was followedThe Sj14-3-3 gene was expressed and secreted into the medium and its molecular weight was about 35000antibody and rSj14-3-3 had a promising immune reactivity.The recombinant Sj14-3-3 of eukaryotic expression in was successfully harvested.

Keywords： development     challenging     rSj14-3-3     resistance     cultural supernatant    

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FOXP3 and Its Cofactors as Targets of Immunotherapies Review

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Engineering 2019, Volume 5, Issue 1,   Pages 115-121 doi: 10.1016/j.eng.2019.01.001

Abstract:

Forkhead box P3 (FOXP3) is a "master regulator" of regulatory T cells (Tregs), which areAs a consequence, the PTMs change the stability of FOXP3 and its capability to regulate gene expressionAlthough FOXP3 per se is not an ideal drug target, deacetylases, acetyltransferases, kinases, and other enzymes that regulate the PTMs of FOXP3 are potential targets to modulate FOXP3 and TregFOXP3" side effects must be considered when inhibitors to these enzymes are used.

Keywords： Treg     Forkhead box P3 (FOXP3)     Post-translational modification     Autoimmune     Cancer    

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Frontiers of Medicine 2024, Volume 18, Issue 1,   Pages 180-191 doi: 10.1007/s11684-023-1003-0

Abstract: However, little is known about the function of Lipin3 in triglyceride (TG) metabolism.Hence, we generated Lipin3 heterozygous knockout (Lipin3-heKO) mice and cultured primary hepatocytesto explore the pathophysiological roles of Lipin3 in TG metabolism.Our study suggested that Lipin3 was a novel disease-causing gene inducing obesity and HTG.We also established a relationship between Lipin3 and mitochondrial dysfunction.

Keywords： Lipin3     Lipin1     hypertriglyceridemia     obesity     mitochondrial dysfunction    

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A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Engineering 2017, Volume 3, Issue 5,   Pages 653-662 doi: 10.1016/J.ENG.2017.05.013

Abstract: With the rapid advancement of three-dimensional (3D) printing and 3D bioprinting technologies, many researchersThis paper reviews the applications of these 3D printing and 3D bioprinting technologies for the fabricationThis review specifically discusses the state of the art along with new developments and trends in 3Dmedical phantoms, radiologically relevant medical phantoms, and physiological medical phantoms) and 3D

Keywords： 3D printing     3D bioprinting     Medical phantom     Regenerated tissue/organ     Scaffold    

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Deep3DSketch-im: rapid high-fidelity AI 3D model generation by single freehand sketches Research Article

Tianrun CHEN;Runlong CAO;Zejian LI;Ying ZANG;Lingyun SUN;

Frontiers of Information Technology & Electronic Engineering 2024, Volume 25, Issue 1,   Pages 149-159 doi: 10.1631/FITEE.2300314

Abstract: content (AIGC) has been remarkable in the language and image fields, but generated three-dimensional (3DThe conventional approach of creating 3D content through computer-aided design (CAD) is labor-intensiveTo address this issue, we propose a -based 3D modeling approach, Deep3D-im, which uses a single freehandDeep3D-im uses a novel data representation called the signed distance field (SDF) to improve the -to-We believe that Deep3D-im has the potential to revolutionize the process of 3D modeling by providing

Keywords： Content creation     Sketch     Three-dimensional (3D) modeling     3D reconstruction     Shape from X     Artificial    

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Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 269-273 doi: 10.1007/s11684-007-0051-1

Abstract: investigate the influence and the related mechanism of the gene on glucose uptake and insulin resistance in 3T3Radioimmunoassay was used to determine glucose uptake in 3T3-L1 cells with different gene expressionreal-time RT-PCR analysis were used to determine the mRNA levels of several glucose transport proteins in 3T3and glycogen synthase kinase-3b (GSK-3)., GSK-3 and p38MAPK, increased with overexpression in 3T3-L1 cells.

Keywords： 3T3-L1     influence     resistance     receptor substrate-1     transport    

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3D-printable self-healing biodegradable materials and their applications

Frontiers of Mechanical Engineering 2024, Volume 19, Issue 3, doi: 10.1007/s11465-024-0787-1

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Combustion and emissions of RP-3 jet fuel and diesel fuel in a single-cylinder diesel engine

Frontiers in Energy 2023, Volume 17, Issue 5,   Pages 664-677 doi: 10.1007/s11708-021-0787-3

Abstract: The combustion characteristics and emission behaviors of RP-3 jet fuel were studied and compared to commercialcrank angle (CA) after top dead center (ATDC)) were adjusted to evaluate the engine performances of RP-3In comparison to diesel fuel, RP-3 jet fuel shows a retarded heat release and lagged combustion phaseAs a result, RP-3 jet fuel features a longer ignition delay (ID) time, a shorter combustion durationCompared with diesel fuel, the nitrogen oxides (NOx) emissions of RP-3 jet fuel are

Keywords： RP-3 jet fuel     diesel     engine     combustion     emissions    

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China Engineering Science 2001 Volume 3 Contents

Strategic Study of CAE 2001, Volume 3, Issue 12,   Pages 96-99

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Function-reversible facets enabling SrTiO3 nanocrystals for improved photocatalytic hydrogen

Frontiers in Energy 2024, Volume 18, Issue 1,   Pages 101-109 doi: 10.1007/s11708-023-0894-4

Abstract: Herein, by using SrTiO3 nanocrystals enclosed by {023} and {001} facets as a model photocatalystfull-facets-utilization led to a much-improved activity for photocatalytic hydrogen, in contrast to those SrTiO3<

Keywords： SrTiO3 nanocrystals     crystal facets     photocatalysis     hydrogen evolution    

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Overoxidized poly(3,4-ethylenedioxythiophene)-overoxidized polypyrrole composite films with enhanced

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 6,   Pages 735-748 doi: 10.1007/s11705-022-2262-z

Abstract: simple and effective method was proposed to improve the electrocatalytic ability of overoxidized poly(3,4

Keywords： overoxidized poly(3     4-ethylenedioxythiophene)-overoxidized polypyrrole     rutin     luteolin     incubation    

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Animage-based approach to the reconstruction of ancient architectures by extracting and arranging 3D

Divya Udayan J,HyungSeok KIM,Jee-In KIM

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 1,   Pages 12-27 doi: 10.1631/FITEE.1400141

Abstract: idea of our approach is to reduce the infinite solutions that might otherwise arise when recovering a 3Dmanual extrapolation and editing techniques with modeling software to assemble and adjust different 3DVariations of a recreated 3D monument to represent an amalgam of various cultures are targeted for future

Keywords： Digital reconstruction     3D virtual world     3D spatial components     Vision and scene understanding    

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Title Author Date Type Operation

mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?

Shi-Yong Sun

Journal Article

Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling

Samuel Chege Gitau,Xuelian Li,Dandan Zhao,Zhenfeng Guo,Haihai Liang,Ming Qian,Lifang Lv,Tianshi Li,Bozhi Xu,Zhiguo Wang,Yong Zhang,Chaoqian Xu,Yanjie Lu,Zhiming Du,Hongli Shan,Baofeng Yang

Journal Article

Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties

YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng

Journal Article

Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice

ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong

Journal Article

FOXP3 and Its Cofactors as Targets of Immunotherapies

Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang

Journal Article

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and

Journal Article

A Review on the 3D Printing of Functional Structures for Medical Phantoms and Regenerated Tissue and

Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang

Journal Article

Deep3DSketch-im: rapid high-fidelity AI 3D model generation by single freehand sketches

Tianrun CHEN;Runlong CAO;Zejian LI;Ying ZANG;Lingyun SUN;

Journal Article

Influence and related mechanism of Retn gene expression on glucose uptake in 3T3-L1 cells

LI Yahui, DONG Shiyuan, YU Chao, JIANG Yu, LI Huaixing, SUN Shuhan

Journal Article

3D-printable self-healing biodegradable materials and their applications

Journal Article

Combustion and emissions of RP-3 jet fuel and diesel fuel in a single-cylinder diesel engine

Journal Article

China Engineering Science 2001 Volume 3 Contents

Journal Article

Function-reversible facets enabling SrTiO3 nanocrystals for improved photocatalytic hydrogen

Journal Article

Overoxidized poly(3,4-ethylenedioxythiophene)-overoxidized polypyrrole composite films with enhanced

Journal Article

Animage-based approach to the reconstruction of ancient architectures by extracting and arranging 3D

Divya Udayan J,HyungSeok KIM,Jee-In KIM

Journal Article