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Adjuvant treatment strategy after curative resection for hepatocellular carcinoma
Wei Zhang, Bixiang Zhang, Xiao-ping Chen
Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 155-169 doi: 10.1007/s11684-021-0848-3
Keywords: hepatocellular carcinoma adjuvant treatment hepatic resection recurrence
Frontiers of Medicine 2024, Volume 18, Issue 3, Pages 538-557 doi: 10.1007/s11684-024-1079-1
Keywords: schistosomiasis hepatic progenitor cell autophagy extracellular vesicle fibrosis miRNA
Li Jiang, Deng Ning, Xiaoping Chen
Frontiers of Medicine 2020, Volume 14, Issue 3, Pages 251-261 doi: 10.1007/s11684-019-0727-3
Keywords: pancreatic fistula pancreatic body and tail resection distal pancreatectomy
Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 4, Pages 536-545 doi: 10.1007/s11705-021-2067-5
Keywords: BCNU glioblastoma recurrence tumor resection nanoparticles hydrogel
Metformin and metabolic diseases: a focus on hepatic aspects
Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu
Frontiers of Medicine 2015, Volume 9, Issue 2, Pages 173-186 doi: 10.1007/s11684-015-0384-0
Keywords: metformin diabetes hepatic steatosis inflammatory response insulin resistance
Ruoxi Zhang, Jing Chen, Diangang Liu, Yu Wang
Frontiers of Medicine 2019, Volume 13, Issue 3, Pages 398-408 doi: 10.1007/s11684-019-0689-5
Keywords: portal hypertension cirrhosis urotensin II palosuran hepatic stellate cell
Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a
Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li
Frontiers of Medicine 2017, Volume 11, Issue 2, Pages 191-202 doi: 10.1007/s11684-017-0512-0
Primary hepatic carcinoma (PHC) is a common malignant tumor in China.review with meta-analysis aimed to assess the effect of TCM combined with Western therapy on primary hepatic
Keywords: traditional Chinese medicine primary hepatic carcinoma meta-analysis
Beneficial effects of preventive cholecystectomy in patients with hepatic cancer
LIU Anzhong, LI Jun, HUA Huwei
Frontiers of Medicine 2008, Volume 2, Issue 2, Pages 139-142 doi: 10.1007/s11684-008-0026-x
Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors
Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng
Frontiers of Medicine 2012, Volume 6, Issue 3, Pages 317-321 doi: 10.1007/s11684-012-0203-9
Keywords: gastrointestinal stromal tumors surgery survival
Endoscopic resection of a huge Brunner's gland adenoma
ZHANG Binbin, REN Xu, TANG Xiufen, CHI Yuxin, SHI Xuesong
Frontiers of Medicine 2008, Volume 2, Issue 4, Pages 414-418 doi: 10.1007/s11684-008-0080-4
Keywords: superior Histological examination endoscopy gastro-intestinal gastrointestinal haemorrhage
Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate
Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU
Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 36-40 doi: 10.1007/s11684-009-0020-y
Keywords: liver cirrhosis beta-elemene hepatic stellate cells angiotensin II receptor angiotensin type 1
Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B
Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen
Frontiers of Medicine 2015, Volume 9, Issue 1, Pages 90-99 doi: 10.1007/s11684-015-0390-2
Gene therapy provides a potential cure for hemophilia B, and significant progress has been achieved in liver-directed gene transfer mediated by adeno-associated viral vectors. Recent clinical trials involving the use of a self-complementary adeno-associated virus serotype 8-human codon-optimized factor IX (AAV8-hFIXco) vector demonstrated encouraging efficacy with hFIX expression stabilized at 1% to 6% of normal level in patients, but safety concerns related to high vector doses are still present. Thus, further improvement of AAV vectors and hFIX expression cassette may positively contribute to the ultimate success of hemophilia B gene therapy. In this study, to obtain a higher expression level of hFIX that potentiates the coagulant capacity of recipients, human FIX expression vector was optimized by upgrading the codon adaption index and adjusting the GC content, inserting a Kozak sequence (GCCACC), and introducing a gain-of-function mutation, R338L (FIX Padua). The efficiency of the published and the presently constructed cassettes was compared through in vivo screening. In addition, the regulatory elements that control the FIX gene expression in these cassettes were screened for liver-specific effectiveness. Among all the constructed cassettes, scAAV-Pre-hFIXco-SIH-R338L, which was the construct under the control of the prothrombin enhancer and prealbumin promoter, resulted in the highest level of coagulant activity, and the expression levels of two constructed cassettes (scAAV-Chi-hFIXco-SIH-R338L and scAAV-Pre-hFIXco-SIH-R338L) were also higher than that of the published cassette (scAAV-LP1-hFIXco-SJ). In summary, our strategies led to a substantial increase in hFIX expression at the protein level or a remarkably elevated coagulant activity. Thus, these reconstructs of hFIX with AAV vector may potentially contribute to the creation of an efficacious gene therapy of hemophilia B.
Keywords: factor IX hemophilia B liver-specific regulatory elements hydrodynamic gene transfer
Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice
CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang
Frontiers of Medicine 2008, Volume 2, Issue 2, Pages 154-165 doi: 10.1007/s11684-008-0029-7
Keywords: cercariae collagen hyaluronic OPMCM soluble
Expression of integrin in hepatic fibrosis and intervention of resveratrol
Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN
Frontiers of Medicine 2009, Volume 3, Issue 1, Pages 100-107 doi: 10.1007/s11684-009-0013-x
Keywords: liver fibrosis integrin-β1 resveratrol tumor growth factor-β tissue inhibitor of metalloproteinase-1
Zhi-Yong ZHANG, Xiao-Ping CHEN, Qi-Ping LU
Frontiers of Medicine 2010, Volume 4, Issue 3, Pages 317-322 doi: 10.1007/s11684-010-0035-4
Keywords: hepatic ischemia-reperfusion digestive tract congestion cholecystokinin vasoactive intestinal peptide
Title Author Date Type Operation
Adjuvant treatment strategy after curative resection for hepatocellular carcinoma
Wei Zhang, Bixiang Zhang, Xiao-ping Chen
Journal Article
Autophagy in hepatic progenitor cells modulates exosomal miRNAs to inhibit liver fibrosis in schistosomiasis
Journal Article
Prevention and treatment of pancreatic fistula after pancreatic body and tail resection: current status
Li Jiang, Deng Ning, Xiaoping Chen
Journal Article
loaded natural extracellular matrix hydrogel for inhibition of glioblastoma recurrence after tumor resection
Journal Article
Metformin and metabolic diseases: a focus on hepatic aspects
Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu
Journal Article
Urotensin II receptor antagonist reduces hepatic resistance and portal pressure through enhanced eNOS-dependent
Ruoxi Zhang, Jing Chen, Diangang Liu, Yu Wang
Journal Article
Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a
Li Ma, Bin Wang, Yuanxiong Long, Hanmin Li
Journal Article
Beneficial effects of preventive cholecystectomy in patients with hepatic cancer
LIU Anzhong, LI Jun, HUA Huwei
Journal Article
Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors
Qinggang Hu, Shanglong Liu, Jianwei Jiang, Chen Zhang, Xiaowei Liu, Qichang Zheng
Journal Article
Endoscopic resection of a huge Brunner's gland adenoma
ZHANG Binbin, REN Xu, TANG Xiufen, CHI Yuxin, SHI Xuesong
Journal Article
Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellate
Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU
Journal Article
Optimized human factor IX expression cassettes for hepatic-directed gene therapy of hemophilia B
Ru Zhang,Qiang Wang,Lin Zhang,Saijuan Chen
Journal Article
Paeoniflorin prevents hepatic fibrosis of by inhibiting TGF-β1 production from macrophages in mice
CHU Deyong, LI Conglei, SHEN Jilong, WU Qiang
Journal Article
Expression of integrin in hepatic fibrosis and intervention of resveratrol
Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN
Journal Article