Antibiotics, especially halogenated antibiotics, as a class of emerging contaminants, which exhibited detrimental effects on aquatic environment and human health have garnered significant scientific attention. Despite advanced oxidation processes (AOPs) are extensively utilized for removing halogenated antibiotics, the halogen moieties exhibit strong resistance to oxidative radicals, thus constraining the dehalogenation and detoxification efficiencies of AOPs. This special issue publishes research on the advanced reduction processes (ARPs) based on carbon dioxide radical anions (CO2●-), which demonstrates that CO2●- based ARPs are efficient for simultaneous degradation, dehalogenation and detoxification of a series of halogenated antibiotics. The formation of halogen-free products is the primary reason for the superior detoxification performance, in comparison with conventional AOPs. This work provides a promising strategy for halogenated antibiotics regulation during wastewater treatment.