Search scope:
排序: Display mode:
Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 549-561 doi: 10.1007/s11684-022-0965-7
Keywords: pregnancy IgG glycome type I interferon systemic lupus erythematosus
Novel Insight into the Etiology of Haff Disease by Mapping the N-Glycome with Orthogonal Mass Article
Si Liu, Yuanyuan Liu, Jiajing Lin, Bi-Feng Liu, Zhenyu He, Xiaomin Wu, Xin Liu
Engineering 2023, Volume 26, Issue 7, Pages 63-73 doi: 10.1016/j.eng.2022.09.012
Keywords: Haff disease Serum Immunoglobulin G Glycosylation Disease pathogenesis
Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 378-388 doi: 10.1007/s11684-021-0840-y
Keywords: severe Mycoplasma pneumoniae pneumonia children proteomics Fc fragment of the IgG-binding protein
High-level expression of recombinant IgG1 by CHO K1 platform
Ningning Xu, Jianfa Ou, Al-Karim (Al) Gilani, Lufang Zhou, Margaret Liu
Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 3, Pages 376-380 doi: 10.1007/s11705-015-1531-5
Keywords: Chinese hamster ovary (CHO) monoclonal antibody IgG1 amplification cell line development
Wei Wang, Baofeng Yang
Engineering 2023, Volume 26, Issue 7, Pages 1-2 doi: 10.1016/j.eng.2023.05.007
IgG N-Glycosylation Cardiovascular Age Tracks Cardiovascular Risk Beyond Calendar Age Article
Zhiyuan Wu, Zheng Guo, Yulu Zheng, Yutao Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Lois Balmer, Xia Li, Lixin Tao, Xiuhua Guo, Wei Wang
Engineering 2023, Volume 26, Issue 7, Pages 99-107 doi: 10.1016/j.eng.2022.12.004
The use of an altered immunoglobulin G (IgG) N-glycan pattern as an inflammation metric hasHowever, the usable capacity of IgG N-glycosylation profiles for the risk stratification of cardiovascularThis study aimed to develop a cardiovascular aging index for tracking cardiovascular risk using IgG
Keywords: IgG N-glycosylation cardiovascular age Cardiovascular aging Immunoglobulin G Glycosylation Inflammation
Huiquan Wu, Erik Read, Maury White, Brittany Chavez, Kurt Brorson, Cyrus Agarabi, Mansoor Khan
Frontiers of Chemical Science and Engineering 2015, Volume 9, Issue 3, Pages 386-406 doi: 10.1007/s11705-015-1533-3
Keywords: technology (PAT) Fourier-transform infrared (FTIR) spectroscopy partial least squares (PLS) regression mouse IgG3
Serum IgG Glycan Hallmarks of Systemic Lupus Erythematosus Article
Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu
Engineering 2023, Volume 26, Issue 7, Pages 89-98 doi: 10.1016/j.eng.2023.01.006
Keywords: Systemic lupus erythematosus N-glycans Diagnostic indicators
Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation Review
Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko
Engineering 2023, Volume 26, Issue 7, Pages 17-31 doi: 10.1016/j.eng.2023.03.013
Keywords: Glycome Glycans N-glycosylation Genomics Genetics GWAS
Profound Diversity of the N-Glycome from Microdissected Regions of Colorectal Cancer, Stroma Article
Di Wang, Katarina Madunić , Tao Zhang, Guinevere S.M. Lageveen-Kammeijer, Manfred Wuhrer
Engineering 2023, Volume 26, Issue 7, Pages 32-43 doi: 10.1016/j.eng.2022.08.016
Aberrant glycosylation is considered to be a hallmark of colorectal cancer (CRC), as demonstrated by various studies. While the N-glycosylation of cell lines and serum has been widely examined, the analysis of cancer-associated N-glycans from tissues has been hampered by the heterogeneity of tumors and the complexity of N-glycan structures. To overcome these obstacles, we present a study using laser capture microdissection that makes it possible to largely deconvolute distinct N-glycomic signatures originating from different regions of heterogeneous tissues including cancerous, stromal, and healthy mucosa cells. N-glycan alditols were analyzed by means of porous graphitized carbon liquid chromatography-electrospray ionization tandem mass spectrometry, enabling the differentiation and structural characterization of isomeric species. In total, 116 N-glycans were identified that showed profound differences in expression among cancer, stroma, and normal mucosa. In comparison with healthy mucosa, the cancer cells showed an increase in α2-6 sialylation and monoantennary N-glycans, as well as a decrease in bisected N-glycans. Moreover, specific sialylated and (sialyl-)LewisA/X antigen-carrying N-glycans were exclusively expressed in cancers. In comparison with cancer, the stroma showed lower levels of oligomannosidic and monoantennary N-glycans, LewisA/X epitopes, and sulfation, as well as increased expression of (core-)fucosylation and α2-3 sialylation. Our study reveals the distinct N-glycomic profiles of different cell types in CRC tumor and control tissues, proving the necessity of their separate analysis for the discovery of cancer-associated glycans.
Keywords: Colorectal cancer Tumor Porous graphitized carbon liquid chromatography mass spectrometry N-glycomics Antibody response
High-Throughput Profiling of Serological Immunoglobulin G N-Glycome as a Noninvasive Biomarker Article
Pengcheng Liu, Xiaobing Wang, Aishe Dun, Yutong Li, Houqiang Li, Lu Wang, Yichun Zhang, Cancan Li, Jinxia Zhang, Xiaoyu Zhang, Lixing Ma, Haifeng Hou
Engineering 2023, Volume 26, Issue 7, Pages 44-53 doi: 10.1016/j.eng.2023.02.008
Immunoglobulin G (IgG) N-glycosylation plays a crucial role in the developmentThis study aimed to evaluate the diagnostic performance of IgG for gastrointestinal (GI) cancer subtypesN-glycome.Canonical correlation analysis (CCA) was used to explore the correlation between IgG N-glycosylationOur findings demonstrate that IgG N-glycosylation plays an important role in modulating the pathogenesis
Keywords: Gastrointestinal cancer Glycosylation Immunoglobulin G Diagnostic biomarker
Title Author Date Type Operation
Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk betweenIgG sialylation and pDC functions
Journal Article
Novel Insight into the Etiology of Haff Disease by Mapping the N-Glycome with Orthogonal Mass
Si Liu, Yuanyuan Liu, Jiajing Lin, Bi-Feng Liu, Zhenyu He, Xiaomin Wu, Xin Liu
Journal Article
Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein
Journal Article
High-level expression of recombinant IgG1 by CHO K1 platform
Ningning Xu, Jianfa Ou, Al-Karim (Al) Gilani, Lufang Zhou, Margaret Liu
Journal Article
IgG N-Glycosylation Cardiovascular Age Tracks Cardiovascular Risk Beyond Calendar Age
Zhiyuan Wu, Zheng Guo, Yulu Zheng, Yutao Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Lois Balmer, Xia Li, Lixin Tao, Xiuhua Guo, Wei Wang
Journal Article
Real time monitoring of bioreactor mAb IgG3 cell culture process dynamics via Fourier transform infrared
Huiquan Wu, Erik Read, Maury White, Brittany Chavez, Kurt Brorson, Cyrus Agarabi, Mansoor Khan
Journal Article
Serum IgG Glycan Hallmarks of Systemic Lupus Erythematosus
Hudan Pan, Jingrong Wang, Yong Liang, Canjian Wang, Ruimin Tian, Hua Ye, Xiao Zhang, Yuanhao Wu, Miao Shao, Ruijun Zhang, Yao Xiao, Zhi Li, Guangfeng Zhang, Hua Zhou, Yilin Wang, Xiaoshuang Wang, Zhanguo Li, Wei Liu, Liang Liu
Journal Article
Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation
Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko
Journal Article
Profound Diversity of the N-Glycome from Microdissected Regions of Colorectal Cancer, Stroma
Di Wang, Katarina Madunić , Tao Zhang, Guinevere S.M. Lageveen-Kammeijer, Manfred Wuhrer
Journal Article