Resource Type

Journal Article 2

Year

2023 1

Keywords

Halomonas bluephagenesis 1

α-acetolactate decarboxylase 1

α-acetolactate synthetase 1

Liver fibrosis 1

Macrophages 1

Nonalcoholic steatohepatitis 1

Pyruvate kinase M2 1

acetoin 1

heteroduplex oligonucleotide 1

nonparenchymal cells 1

pyruvate 1

whole-cell biocatalysis 1

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Efficient acetoin production from pyruvate by engineered whole-cell biocatalysis

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 4,   Pages 425-436 doi: 10.1007/s11705-022-2229-0

Abstract: Bacillus subtilis 168 were co-expressed in H. bluephagenesis to produce acetoin from pyruvate

Keywords： acetoin     pyruvate     α-acetolactate synthetase     α-acetolactate decarboxylase     Halomonas    

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Therapeutic Targeting of PKM2 Ameliorates NASH Fibrosis Progression in A Macrophage-Specific and Liver-Specific Manner

Hengdong Qu,Di Zhang,Junli Liu,Jieping Deng,Ruoyan Xie,Keke Zhang,Hongmei Li,Ping Tao,Genshu Wang,Jian Sun,Oscar Junhong Luo,Chen Qu,Wencai Ye,Jian Hong,

Engineering doi: 10.1016/j.eng.2024.05.005

Abstract: Pyruvate kinase M2 (PKM2) is involved in immune activation and inflammatory liver diseases; however,

Keywords： Pyruvate kinase M2     Macrophages     nonparenchymal cells     heteroduplex oligonucleotide     Nonalcoholic steatohepatitis    

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Title Author Date Type Operation

Efficient acetoin production from pyruvate by engineered whole-cell biocatalysis

Journal Article

Therapeutic Targeting of PKM2 Ameliorates NASH Fibrosis Progression in A Macrophage-Specific and Liver-Specific Manner

Hengdong Qu,Di Zhang,Junli Liu,Jieping Deng,Ruoyan Xie,Keke Zhang,Hongmei Li,Ping Tao,Genshu Wang,Jian Sun,Oscar Junhong Luo,Chen Qu,Wencai Ye,Jian Hong,

Journal Article