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Xiaoliu LI, Xinhao YAN, Zhiwei LI, Hua CHEN, Pingzhu ZHANG,
Frontiers of Chemical Science and Engineering 2010, Volume 4, Issue 3, Pages 342-347 doi: 10.1007/s11705-009-0279-1
Keywords: photoelectron spectroscopy adsorption-desorption glycosylation deactivated diffraction
Emerging roles of podoplanin in vascular development and homeostasis
Yanfang Pan,Lijun Xia
Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 421-430 doi: 10.1007/s11684-015-0424-9
Podoplanin (PDPN) is a mucin-type O-glycoprotein expressed in diverse cell types, such as lymphatic endothelial cells (LECs) in the vascular system and fibroblastic reticular cells (FRCs) in lymph nodes. PDPN on LECs or FRCs activates CLEC-2 in platelets, triggering platelet activation and/or aggregation through downstream signaling events, including activation of Syk kinase. This mechanism is required to initiate and maintain separation of blood and lymphatic vessels and to stabilize high endothelial venule integrity within lymph nodes. In the vascular system, normal expression of PDPN at the LEC surface requires transcriptional activation of Pdpn by Prox1 and modification of PDPN with core 1-derived O-glycans. This review provides a comprehensive overview of the roles of PDPN in vascular development and lymphoid organ maintenance and discusses the mechanisms that regulate PDPN expression related to its function.
Keywords: podoplanin CLEC-2 Prox1 O-glycosylation lymphatic vascular development and maintenance lymphoid
Corrigendum to “Bidirectional Causality Between Immunoglobulin G N-Glycosylation and Metabolic Traits Corrigendum
Xiaoni Meng, Weijie Cao, Di Liu, Isinta Elijah Maranga, Weijia Xing, Haifeng Hou, Xizhu Xu, Manshu Song, Youxin Wang
Engineering 2024, Volume 38, Issue 7, Pages 234-234 doi: 10.1016/j.eng.2024.05.011
IgG N-Glycosylation Cardiovascular Age Tracks Cardiovascular Risk Beyond Calendar Age Article
Zhiyuan Wu, Zheng Guo, Yulu Zheng, Yutao Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Lois Balmer, Xia Li, Lixin Tao, Xiuhua Guo, Wei Wang
Engineering 2023, Volume 26, Issue 7, Pages 99-107 doi: 10.1016/j.eng.2022.12.004
Keywords: IgG N-glycosylation cardiovascular age Cardiovascular aging Immunoglobulin G Glycosylation Inflammation
Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients Article
Marina Kljaković-Gašpić Batinjan, Tea Petrović, Frano Vučković, Irzal Hadžibegović, Barbara Radovani, Ivana Jurin, Lovorka Đerek, Eva Huljev, Alemka Markotić, Ivica Lukšić, Irena Trbojević-Akmačić, Gordan Lauc, Ivan Gudelj, Rok Čivljak
Engineering 2023, Volume 26, Issue 7, Pages 54-62 doi: 10.1016/j.eng.2022.08.007
Keywords: Influenza COVID-19 Viral infection Glycosylation Immunoglobulin G Pneumonia
The Notch Signaling Pathway: Mechanistic Insights in Health and Disease Review
Yao Meng, Zhihan Bo, Xinyi Feng, Xinyi Yang, Penny A. Handford
Engineering 2024, Volume 34, Issue 3, Pages 212-232 doi: 10.1016/j.eng.2023.11.011
The Notch signaling pathway is evolutionarily conserved across metazoan species and plays key roles in many physiological processes. The Notch receptor is activated by two families of canonical ligands (Delta and Serrate/Jagged) where both ligands and receptors are single-pass transmembrane proteins usually with large extracellular domains, relative to their intracellular portions. Upon interaction of the core binding regions, presented on opposing cell surfaces, formation of the receptor/ligand complex initiates force-mediated proteolysis, ultimately releasing the transcriptionally-active Notch intracellular domain. This review focuses on structural features of the extracellular receptor/ligand complex, the role of post-translational modifications in tuning this complex, the contribution of the cell membrane to ligand function, and insights from acquired and genetic diseases.
Keywords: Notch signaling pathway Structural biology Glycosylation Genetic disorders Cancer Pharmacological
Xiaoni Meng, Weijie Cao, Di Liu, Isinta Maranga Elijah, Weijia Xing, Haifeng Hou, Xizhu Xu, Manshu Song, Youxin Wang
Engineering 2023, Volume 26, Issue 7, Pages 74-88 doi: 10.1016/j.eng.2022.11.004
Bidirectional causalityAlthough the association between immunoglobulin G (IgG) N-glycosylation andin the reverse MR analysis of the integrated metabolic-QTL variants with the GWAS results for IgG N-glycosylationGP9 (HDL-C)) genetically determined metabolic traits were found to be related to the risk of IgG N-glycosylationcomprehensively bidirectional MR analyses provide suggestive evidence of bidirectional causality between IgG N-glycosylationand metabolic traits, possibly revealing a new richness in the biological mechanism between IgG N-glycosylation
Keywords: Mendelian randomization study Immunoglobulin G N-glycosylation Metabolic traits Quantitative trait
Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation Review
Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko
Engineering 2023, Volume 26, Issue 7, Pages 17-31 doi: 10.1016/j.eng.2023.03.013
Keywords: Glycome Glycans N-glycosylation Genomics Genetics GWAS
Periodic Changes in the N-Glycosylation of Immunoglobulin G During the Menstrual Cycle Article
Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc
Engineering 2023, Volume 26, Issue 7, Pages 108-118 doi: 10.1016/j.eng.2022.10.020
Keywords: N-glycosylation Immunoglobulin G Menstrual cycle Female sex hormones Estrogen Progesterone Testosterone
Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 322-338 doi: 10.1007/s11684-021-0901-2
Keywords: cancer immunotherapy chimeric antigen receptor solid tumors tumor-associated antigen glycosylation
Hui Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang, Yao Sun
Frontiers of Medicine 2019, Volume 13, Issue 5, Pages 575-589 doi: 10.1007/s11684-019-0693-9
Keywords: fracture extracellular matrix dentin matrix protein 1 proteoglycan cartilage
Si Liu, Yuanyuan Liu, Jiajing Lin, Bi-Feng Liu, Zhenyu He, Xiaomin Wu, Xin Liu
Engineering 2023, Volume 26, Issue 7, Pages 63-73 doi: 10.1016/j.eng.2022.09.012
Keywords: Haff disease Serum Immunoglobulin G Glycosylation Disease pathogenesis
Human Prostate-Specific Antigen Carries N-Glycans with Ketodeoxynononic Acid Article
Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer
Engineering 2023, Volume 26, Issue 7, Pages 119-131 doi: 10.1016/j.eng.2023.02.009
Keywords: Ketodeoxynononic acid Kdn Glycosylation Prostate cancer Prostate-specific antigen
Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li
Engineering 2021, Volume 7, Issue 10, Pages 1441-1451 doi: 10.1016/j.eng.2020.07.014
Keywords: N-glycosylation COVID-19 Spike protein hACE2 Structure
Transcription Factors HNF1A, HNF4A, and FOXA2 Regulate Hepatic Cell Protein N-Glycosylation Article
Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš
Engineering 2024, Volume 32, Issue 1, Pages 57-68 doi: 10.1016/j.eng.2023.09.019
Keywords: factor 1 alpha (HNF1A) Hepatocyte nuclear factor 4 alpha (HNF4A) Forkhead box protein A2 (FOXA2) N-glycosylation
Title Author Date Type Operation
Catalysis and deactivation of montmorillonite K10 in the aryl O -glycosylation of glycosyl trichloroacetoimidates
Xiaoliu LI, Xinhao YAN, Zhiwei LI, Hua CHEN, Pingzhu ZHANG,
Journal Article
Emerging roles of podoplanin in vascular development and homeostasis
Yanfang Pan,Lijun Xia
Journal Article
Corrigendum to “Bidirectional Causality Between Immunoglobulin G N-Glycosylation and Metabolic Traits
Xiaoni Meng, Weijie Cao, Di Liu, Isinta Elijah Maranga, Weijia Xing, Haifeng Hou, Xizhu Xu, Manshu Song, Youxin Wang
Journal Article
IgG N-Glycosylation Cardiovascular Age Tracks Cardiovascular Risk Beyond Calendar Age
Zhiyuan Wu, Zheng Guo, Yulu Zheng, Yutao Wang, Haiping Zhang, Huiying Pan, Zhiwei Li, Lois Balmer, Xia Li, Lixin Tao, Xiuhua Guo, Wei Wang
Journal Article
Differences in Immunoglobulin G Glycosylation Between Influenza and COVID-19 Patients
Marina Kljaković-Gašpić Batinjan, Tea Petrović, Frano Vučković, Irzal Hadžibegović, Barbara Radovani, Ivana Jurin, Lovorka Đerek, Eva Huljev, Alemka Markotić, Ivica Lukšić, Irena Trbojević-Akmačić, Gordan Lauc, Ivan Gudelj, Rok Čivljak
Journal Article
The Notch Signaling Pathway: Mechanistic Insights in Health and Disease
Yao Meng, Zhihan Bo, Xinyi Feng, Xinyi Yang, Penny A. Handford
Journal Article
Bidirectional Causality Between Immunoglobulin G N-Glycosylation and Metabolic Traits: A Mendelian Randomization
Xiaoni Meng, Weijie Cao, Di Liu, Isinta Maranga Elijah, Weijia Xing, Haifeng Hou, Xizhu Xu, Manshu Song, Youxin Wang
Journal Article
Twelve Years of Genome-Wide Association Studies of Human Protein N-Glycosylation
Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko
Journal Article
Periodic Changes in the N-Glycosylation of Immunoglobulin G During the Menstrual Cycle
Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc
Journal Article
CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a sweet success?
Journal Article
Glycosylation of dentin matrix protein 1 is critical for fracture healing via promoting chondrogenesis
Hui Xue, Dike Tao, Yuteng Weng, Qiqi Fan, Shuang Zhou, Ruilin Zhang, Han Zhang, Rui Yue, Xiaogang Wang, Zuolin Wang, Yao Sun
Journal Article
Novel Insight into the Etiology of Haff Disease by Mapping the N-Glycome with Orthogonal Mass Spectrometry
Si Liu, Yuanyuan Liu, Jiajing Lin, Bi-Feng Liu, Zhenyu He, Xiaomin Wu, Xin Liu
Journal Article
Human Prostate-Specific Antigen Carries N-Glycans with Ketodeoxynononic Acid
Wei Wang, Tao Zhang, Jan Nouta, Peter A. van Veelen, Noortje de Haan, Theo M. de Reijke, Manfred Wuhrer, Guinevere S.M. Lageveen-Kammeijer
Journal Article
Mass Spectrometry Analysis of Newly Emerging Coronavirus HCoV-19 Spike Protein and Human ACE2 Reveals Camouflaging Glycans and Unique Post-Translational Modifications
Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li
Journal Article